LymphedemaV1, Main, Exploration, bibRecord, 007931

Lymphangiogenic Growth Factor Responsiveness Is Modulated by Postnatal Lymphatic Vessel Maturation

Identifieur interne : 007931 ( Main/Exploration ); précédent : 007930; suivant : 007932

Lymphangiogenic Growth Factor Responsiveness Is Modulated by Postnatal Lymphatic Vessel Maturation

Auteurs : Terhi Karpanen ; Maria Wirzenius ; Taija M Kinen ; Tanja Veikkola ; Hidde J. Haisma ; Marc G. Achen ; Steven A. Stacker ; Bronislaw Pytowski ; Seppo Yl Herttuala ; Kari Alitalo [Finlande]

Source :

The American Journal of Pathology [ 0002-9440 ] ; 2006.

RBID : PMC:1764216

Abstract

Lymphatic vessel plasticity and stability are of considerable importance when attempting to treat diseases associated with the lymphatic vasculature. Development of lymphatic vessels during embryogenesis is dependent on vascular endothelial growth factor (VEGF)-C but not VEGF-D. Using a recombinant adenovirus encoding a soluble form of their receptor VEGFR-3 (AdVEGFR-3-Ig), we studied lymphatic vessel dependency on VEGF-C and VEGF-D induced VEGFR-3 signaling in postnatal and adult mice. Transduction with AdVEGFR-3-Ig led to regression of lymphatic capillaries and medium-sized lymphatic vessels in mice under 2 weeks of age without affecting collecting lymphatic vessels or the blood vasculature. No effect was observed after this period. The lymphatic capillaries of neonatal mice also regressed partially in response to recombinant VEGFR-3-Ig or blocking antibodies against VEGFR-3, but not to adenovirus-encoded VEGFR-2-Ig. Despite sustained inhibitory VEGFR-3-Ig levels, lymphatic vessel regrowth was observed at 4 weeks of age. Interestingly, whereas transgenic expression of VEGF-C in the skin induced lymphatic hyperplasia even during embryogenesis, similar expression of VEGF-D resulted in lymphangiogenesis predominantly after birth. These results indicate considerable plasticity of lymphatic vessels during the early postnatal period but not thereafter, suggesting that anti-lymphangiogenic therapy can be safely applied in adults.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764216

DOI: 10.2353/ajpath.2006.051200
PubMed: 16877368
PubMed Central: 1764216

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphangiogenic Growth Factor Responsiveness Is Modulated by Postnatal Lymphatic Vessel Maturation</title>
<author><name sortKey="Karpanen, Terhi" sort="Karpanen, Terhi" uniqKey="Karpanen T" first="Terhi" last="Karpanen">Terhi Karpanen</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wirzenius, Maria" sort="Wirzenius, Maria" uniqKey="Wirzenius M" first="Maria" last="Wirzenius">Maria Wirzenius</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Veikkola, Tanja" sort="Veikkola, Tanja" uniqKey="Veikkola T" first="Tanja" last="Veikkola">Tanja Veikkola</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Haisma, Hidde J" sort="Haisma, Hidde J" uniqKey="Haisma H" first="Hidde J." last="Haisma">Hidde J. Haisma</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G." last="Achen">Marc G. Achen</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A." last="Stacker">Steven A. Stacker</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pytowski, Bronislaw" sort="Pytowski, Bronislaw" uniqKey="Pytowski B" first="Bronislaw" last="Pytowski">Bronislaw Pytowski</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
<country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">16877368</idno>
<idno type="pmc">1764216</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764216</idno>
<idno type="RBID">PMC:1764216</idno>
<idno type="doi">10.2353/ajpath.2006.051200</idno>
<date when="2006">2006</date>
<idno type="wicri:Area/Pmc/Corpus">002B69</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002B69</idno>
<idno type="wicri:Area/Pmc/Curation">002B68</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002B68</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003C59</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003C59</idno>
<idno type="wicri:Area/Ncbi/Merge">002350</idno>
<idno type="wicri:Area/Ncbi/Curation">002350</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002350</idno>
<idno type="wicri:doubleKey">0002-9440:2006:Karpanen T:lymphangiogenic:growth:factor</idno>
<idno type="wicri:Area/Main/Merge">007B12</idno>
<idno type="wicri:Area/Main/Curation">007931</idno>
<idno type="wicri:Area/Main/Exploration">007931</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lymphangiogenic Growth Factor Responsiveness Is Modulated by Postnatal Lymphatic Vessel Maturation</title>
<author><name sortKey="Karpanen, Terhi" sort="Karpanen, Terhi" uniqKey="Karpanen T" first="Terhi" last="Karpanen">Terhi Karpanen</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wirzenius, Maria" sort="Wirzenius, Maria" uniqKey="Wirzenius M" first="Maria" last="Wirzenius">Maria Wirzenius</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Veikkola, Tanja" sort="Veikkola, Tanja" uniqKey="Veikkola T" first="Tanja" last="Veikkola">Tanja Veikkola</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Haisma, Hidde J" sort="Haisma, Hidde J" uniqKey="Haisma H" first="Hidde J." last="Haisma">Hidde J. Haisma</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G." last="Achen">Marc G. Achen</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A." last="Stacker">Steven A. Stacker</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pytowski, Bronislaw" sort="Pytowski, Bronislaw" uniqKey="Pytowski B" first="Bronislaw" last="Pytowski">Bronislaw Pytowski</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
<affiliation><nlm:aff id="d29e89"></nlm:aff>
<country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">The American Journal of Pathology</title>
<idno type="ISSN">0002-9440</idno>
<idno type="eISSN">1525-2191</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Lymphatic vessel plasticity and stability are of considerable importance when attempting to treat diseases associated with the lymphatic vasculature. Development of lymphatic vessels during embryogenesis is dependent on vascular endothelial growth factor (VEGF)-C but not VEGF-D. Using a recombinant adenovirus encoding a soluble form of their receptor VEGFR-3 (AdVEGFR-3-Ig), we studied lymphatic vessel dependency on VEGF-C and VEGF-D induced VEGFR-3 signaling in postnatal and adult mice. Transduction with AdVEGFR-3-Ig led to regression of lymphatic capillaries and medium-sized lymphatic vessels in mice under 2 weeks of age without affecting collecting lymphatic vessels or the blood vasculature. No effect was observed after this period. The lymphatic capillaries of neonatal mice also regressed partially in response to recombinant VEGFR-3-Ig or blocking antibodies against VEGFR-3, but not to adenovirus-encoded VEGFR-2-Ig. Despite sustained inhibitory VEGFR-3-Ig levels, lymphatic vessel regrowth was observed at 4 weeks of age. Interestingly, whereas transgenic expression of VEGF-C in the skin induced lymphatic hyperplasia even during embryogenesis, similar expression of VEGF-D resulted in lymphangiogenesis predominantly after birth. These results indicate considerable plasticity of lymphatic vessels during the early postnatal period but not thereafter, suggesting that anti-lymphangiogenic therapy can be safely applied in adults.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Finlande</li>
</country>
<region><li>Uusimaa</li>
</region>
<settlement><li>Helsinki</li>
</settlement>
<orgName><li>Université d'Helsinki</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G." last="Achen">Marc G. Achen</name>
<name sortKey="Haisma, Hidde J" sort="Haisma, Hidde J" uniqKey="Haisma H" first="Hidde J." last="Haisma">Hidde J. Haisma</name>
<name sortKey="Karpanen, Terhi" sort="Karpanen, Terhi" uniqKey="Karpanen T" first="Terhi" last="Karpanen">Terhi Karpanen</name>
<name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name>
<name sortKey="Pytowski, Bronislaw" sort="Pytowski, Bronislaw" uniqKey="Pytowski B" first="Bronislaw" last="Pytowski">Bronislaw Pytowski</name>
<name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A." last="Stacker">Steven A. Stacker</name>
<name sortKey="Veikkola, Tanja" sort="Veikkola, Tanja" uniqKey="Veikkola T" first="Tanja" last="Veikkola">Tanja Veikkola</name>
<name sortKey="Wirzenius, Maria" sort="Wirzenius, Maria" uniqKey="Wirzenius M" first="Maria" last="Wirzenius">Maria Wirzenius</name>
<name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name>
</noCountry>
<country name="Finlande"><region name="Uusimaa"><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007931 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007931 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:1764216
   |texte=   Lymphangiogenic Growth Factor Responsiveness Is Modulated by Postnatal Lymphatic Vessel Maturation
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:16877368" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

Lymphangiogenic Growth Factor Responsiveness Is Modulated by Postnatal Lymphatic Vessel Maturation

Lymphangiogenic Growth Factor Responsiveness Is Modulated by Postnatal Lymphatic Vessel Maturation

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.